Compounds regularly appear with health benefits. This particular compound, magnesium L-threonate (CAS no. 778571-57-6, and the hydrate is CAS no. 500304-76-7) is being marketed as a memory enhancer and cognition improver. The initial study that demonstrated this effect was conducted in rats (Slutsky et al., 2010). It was demonstrated that brain function measured through synaptic enhancement led to improvements in working memory, learning ability, and short- and long term memory in both juvenile and adult rats. The benefits were attributed to higher levels of brain magnesium rather than threonate.
Human intervention studies are still needed to support these findings even though it is sold as a dietary supplement. The supplement is available from AIDP Inc., City of Industry, Calif. USA (T: 001 866-262-6699, www.magtein.com). US Patents for ADIP describe its manufacture and applications.
Magnesium as a mineral in its own right is important for energy metabolism and in many other aspects of nutrition. There is also a link with zinc and L-theanine which are tow other ingredients associated with good sleep and cognitive benefit.
Products Containing Magnesium L-Threonate
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Slutsky, I., Abumaria, N., Wu, L.J., Huang, C., Zhang, L., Li, B. et al. (2010) Enhancement of learning and memory by elevating brain magnesium. Neuron 65 pp. 165–177