Issues With Calcium Supplements

White calcium pills pouring out of bottle. calcium supplements are an important OTC product.
Copyright: Jimmy Lopes

Some folks have to take calcium supplements especially if they are dealing with osteoporosis or forms of malabsorption where not enough calcium might be entering the body.

One particularly useful ingredient is calcium aspartate which occurs in its anhydrous form (meaning it is a molecule that is not associated with water). The calcium is linked to l-aspartic acid which is a nonessential amino acid. Some clinical evidence suggests that this form has a higher absorption rate than other calcium supplements.  Too much calcium can however have dramatic consequences which supplementers need to be wary of.

There is also a situation for those with sarcoidioisis for example where too much sun can lead to over production of vitamin D by particular skin granulomas and as a consequence too much calcium is then solubilised as a consequence.

Drug Interactions With Calcium Supplements

Supplementation with any calcium salt can interfere with the absorption of prescription and over-the-counter medicines. One particular consequence of a high calcium load is interference with iron absorption. Calcium supplementation is not wholly recommended for those with anemia. Calcium aspartate may also interfere with antibiotic absorption as with tetracycline. 

Kidney Stones

An excess amount of calcium in the body, especially in the blood stream can lead to the formation of kidney stones. the condition called hypercalciuria occurs when there is too much calcium in the urine. It is associated with 90 per cent of all cases involving kidney stones. The web-site MayoClinic.com provides detailed advice on the types of food to eat which are low in calcium and that do not contribute or exacerbate kidney stone formation. It is worth noting that most food consume does not contribute to the issue but calcium supplementation is a major issue.

Constipation

There is some anecdotal evidence that too much calcium especially in the form of calcium aspartate may increase binding and cause flatulence. Constipation is said to be mild but there are other medicines and supplements which complicate the issue and may with calcium supplementation increase the effect.

Stomach Issues

Too much calcium supplementation including calcium aspartate produces loss of appetite, stomach gripes and pain, nausea and even vomiting. The recommendation with calcium aspartate is that no more than 500mg is taken in any one dose (serving) because the form is so bioavailable compared to other formats. 

Talk to your doctor or pharmacist about the use of calcium supplements and the possible drug interactions. 

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2 Comments

  1. I have a number of patients who are taking calcium for alleviating premenstrual syndrome. Any thoughts on a suitable dissolvable tablet?

  2. Dear Ahmed,

    Many thanks for your question. I know that a number of patients have been using calcium to help reduce the issues associated with premenstrual syndrome. I understand that you can take between 1g and 1.3 g of calcium in the form of calcium citrate. I always recommend though that you consult with the OTC supplier given you are already a healthcare practitioner to establish whether any product you recommend is actually a good fit for your and your patient’s needs.

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