Helicobacter pylori Infection

Helicobacter pylori (HP) infection is one of the most common causes of many diseases of the gastrointestinal tract, including non-ulcer dyspepsia, peptic ulcer, gastritis and gastric cancer (Jung et al., 2015; Mansour-Ghanaei et al., 2015; Paydas, 2015).

The best treatments rely on a strategy of many drugs including a proton pump inhibitor and combination of two or more antibiotics. The antibiotics most often used are clarithromycin (CLA), amoxicillin (AMX) and metronidazole (MTZ) or tetracycline (TET) (Nagahara et al., 2000; Chaabane-Al-Adhba, 2015).

References

Chaabane, N.B., Al-Adhba, H.S. (2015) Ciprofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: a randomized trial. Indian J. Gastroenterol. 34 pp. 68–72.

Jung, S.W., Thamphiwatana, S., Zhang, L., Obonyo, M. (2015) Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. PLoS One 10:e0116519.

Mansour-Ghanaei, F., Joukar, F., Mojtahedi, K., Sokhanvar, H., Askari, K., Shafaeizadeh, A. (2015) Does treatment of Helicobacter pylori infection reduce gastric precancerous lesions? Asian Pac J Cancer Prev. 16 pp. 1571–1574

Nagahara, A., Miwa, H., Ogawa, K., Kurosawa, A., Ohkura, R., Iida, N., Sato, N. (2000) Addition of metronidazole to rabeprazole–amoxicillin–clarithromycin regimen for Helicobacter pylori infection provides an excellent cure rate with five-day therapy. Helicobacter 5 pp. 88–93.

Paydas, S. (2015) Helicobacter pylori eradication in gastric diffuse large B cell lymphoma. World J. Gastroenterol. 21 pp. 3773–3776.

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